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Although oral semaglutide might be a better option for patients who are allergic to injections or reluctant to self-inject, its efficacy may be limited by its stringent administration guidelines, which call for taking it half an hour before the first meal, drink, or other medication [90]

Current anti-obesity pharmacotherapy includes 5 FDA-approved medications: orlistat, phentermine-topiramate, naltrexone-bupropion, liraglutide, and semaglutide (Table 2), as well as phentermine, which is approved only for short term use

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Growing patient interest, especially among wellness-focused individuals and athletes, has contributed to this shift